The Park Lab aims to apply quantitative and holistic understanding of metabolic networks to solving energy and environmental challenges and curing human diseases.

• Li, S. H.-J., Li, Z., Park, J. O., King, C. G., Rabinowitz, J. D., Wingreen, N. S., Gitai, Z. Escherichia coli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions. Nature Microbiology (2018) doi: 10.1038/s41564-018-0199-2
• Tanner, L. B., Goglia, A. G., Wei, M. H., Sehgal, T., Parsons, L. R., Park, J. O., White, E., Toettcher, J. E., Rabinowitz, J. D. Four Key Steps Control Glycolytic Flux in Mammalian Cells. Cell Systems (2018) doi: 10.1016/j.cels.2018.06.003
• Miller, R. A., Shi, Y., Lu, W., Pirman, D. A., Jatkar, A., Blatnik, M., Wu, H., Cardenas, C., Wan, M., Foskett, J. K., Park, J. O., Zhang, Y., Holland, W. L., Rabinowitz, J. D., Birnbaum, M. J. Targeting hepatic glutaminase activity to ameliorate hyperglycemia. Nature Medicine (2018) doi: 10.1038/nm.4514
• Song, Y., Marmion, R. A., Park, J. O., Biswas, D., Rabinowitz, J. D., Shvartsman, S. Y. Dynamic control of dNTP synthesis in early embryos.Developmental Cell 42,1-8 (2017) doi: 10.1016/j.devcel.2017.06.013
• Schober, A. F., Ingle, C., Park, J. O., Chen, L., Rabinowitz, J. D., Junier, I., Rivoire. O., Reynolds, K. A. An evolutionary module in central metabolism.bioRxiv (2017)
• Hackett, S. R., Zanotelli, V. R. T., Xu, W., Goya, J., Park, J. O., Perlman, D. H., Gibney, P. A., Botstein, D., Storey, J. D., Rabinowitz, J. D. Systems-level analysis of mechanisms regulating yeast metabolic flux. Science 354:aaf2786 (2016) doi: 10.1126/science.aaf2786
• Liu, L., Chen, L., Ducker, G., Park, J. O., Shah, S., Wellen, K. E., Rabinowitz, J. D. Quantification of NADPH balance in cancer. Cancer Research 76(14 Suppl):1013 (2016) doi: 10.1158/1538-7445.AM2016-1013
• Park, J. O., Rubin, S. A., Xu, Y. F., Amador-Noguez, D., Fan, J., Shlomi, T., Rabinowitz, J. D. Metabolite concentrations, fluxes and free energies imply efficient enzyme usage. Nature Chemical Biology 12:482-489 (2016) doi: 10.1038/nchembio.2077
• Bren, A., Park, J. O., Towbin, B. D., Dekel, E., Rabinowitz, J. D., Alon, U. Glucose becomes one of the worst carbon sources for E. coli on poor nitrogen sources due to suboptimal levels of cAMP. Scientific Reports 6:24834 (2016) doi: 10.1038/srep24834
• Liu, L., Shah, S., Fan, J., Park, J. O., Wellen, K. E., Rabinowitz, J. D. Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage. Nature Chemical Biology 12:345-352 (2016) doi: 10.1038/nchembio.2047
• Mok, W. W. K., Park, J. O., Rabinowitz, J. D., Brynildsen, M. P. RNA futile cycling in model persisters derived from MazF accumulation. mBio6(6):e01588-15 (2015) doi: 10.1128/mBio.01588-15
• Aristilde, L., Lewis, I. A., Park, J. O., Rabinowitz, J. D. Hierarchy in pentose sugar metabolism in Clostridium Acetobutylicum. Applied and Environmental Microbiology 81:1452-1462 (2015) doi: 10.1128/AEM.03199-14
• Park, J. O., Rubin, S. A., Xu, Y. F., Amador-Noguez, D., Fan, J., Rabinowitz, J. D. Comprehensive quantitation of metabolite concentrations, gross reaction fluxes, and reaction free energies across cells from four organisms. Cancer & Metabolism 2(Suppl 1):P54 (2014) doi: 10.1186/2049-3002-2-S1-P54
• Schellenberger, J., Park, J. O., Conrad, T. M., Palsson, B. Ø. BiGG: A Biochemical Genetic and Genomic knowledgebase of large scale metabolic reconstructions. BMC Bioinformatics 11:213 (2010) doi: 10.1186/1471-2105-11-213

• Light-Independent Biological Conversion of CO₂ | Science Direct

• B.A. & B.S., UC San Diego, 2010
• M.S., Princeton, 2012
• Ph.D., Princeton, 2016
• Postdoc, MIT, 2018