Cun Yu Wang

Cun Yu Wang

PROFESSOR
BIOENGINEERING

Chair and No-Hee Park-Endowed Professor, Division of Oral Biology and Medicine, School of Dentistry; Associate Dean for Graduate Studies, School of Dentistry

CHS 33-030A

Email:
Phone: (310) 825-4415

RESEARCH AND INTERESTS
  1. Molecular Signaling (NF-κB and Wnt)
  2. Tumor-invasive growth and Metastasis
  3. Adult mesenchymal stem cells, dental stem cells and regenerative medicine
  4. Inflammation and innate immunity
PUBLICATIONS
  1. Ding X., Pan H., Li. J., Zhong Q., Chen X., Dry S.M., Wang C.Y., “Epigenetic activation of AP-1 promotes squamous cell carcinoma metastasis.” Science Signaling, 2013 in press.
  2. Bianco P., Cao X., Frenette P.S., Mao J.J., Robey P.G., Simmons P.J., Wang C.Y., “The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine.” Nat Med. 2013 Jan;19(1):35-42. Epub 2013 Jan 7.
  3. Ye L., Fan Z., Yu b., Chang J., Al Hezaimi K., Zhou X., Park N.H., Wang C.Y., “Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs.” Cell Stem Cell. 2012 Jul 6;11(1):50-61
  4. Zhao B., Li L., Wang L., Wang C.Y., Yu J., Guan K.L., “Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis.” Genes Dev. 2012 Jan 1;26(1):54-68.
  5. Krum S.A., Chang J., Miranda-Carboni G., Wang C.Y. “Novel functions for NFκB: inhibition of bone formation.” Nat Rev Rheumatol. 2010 Oct:6(10):607-11
  6. Song H., Mak K.K., Topol L., Yun K., Hu J., Garrett L., Chen Y., Park O., Chang J., Simpson R.M., Wang C.Y., Gao B., Jiang J., Yang Y. “Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression.” Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1431-6.
  7. Fan Z., Yamaza T., Lee J.S., Yu J., Wang S., Fan G., Shi S., Wang C.Y. “BCOR regulates mesenchymal stem cell function by epigenetic mechanisms.” Nat Cell Biol. 2009 Aug:11(8):1002-9.
  8. Chang J., Wang Z., Tang E., Fan Z., McCauley L., Franceschi R., Guan K., Krebsbach P.H., Wang C.Y. Inhibition of osteoblastic bone formation by nuclear factor-kappaB. Nat Med 2009 Jun:15(6):682-9.
  9. Li J., Wang C.Y., “TBL-1TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis.” Nat Cell Biol. 2008 Feb:10(2):160-9.
  10. Park B.K., Zhang H., Zeng Q., Dai J., Keller E.T., Giordano T., Gu K., Shah V., Pei L., Zarbo R.J., McCauley L., Shi S., Chen S., Wang C.Y. “NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF.” Nat Med 2007 Jan:13(1):62-9.
EDUCATION
  • B.D.S., Stomatology, Nanjing Medical University, 1985
  • D.D.S., Pediatric Dentistry, Peking University School of Dentistry, 1989
  • Postdoctoral, Immunology and Cytokine Biology, Forsyth Institute, 1995
  • Ph.D., Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 1998
AWARDS AND RECOGNITION
  • Member, Institute of Medicine of National Academies, 2011
  • AAAS Fellow, 2011
  • Distinguished Scientist Award for Basic Research in Biological Mineralization, International Association for Dental Research, 2013
  • No-Hee Park Endowed Professor in Dentistry, 2009
  • Distinguished Scientist Award for Oral Pathology and Medicine, International Association for Dental Research, 2009

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